Understanding Bioavailability

Bioavailability refers to the proportion of a peptide that enters circulation and can produce an active effect. Several factors influence peptide bioavailability.

Administration Methods

Subcutaneous Injection

The most common and effective method:

• Bioavailability: 80-95%
• Onset: 15-30 minutes
• Best sites: Abdomen, thighs, upper arms
• Rotate injection sites to prevent lipohypertrophy

Intramuscular Injection

Faster absorption for certain peptides:

• Bioavailability: 85-100%
• Onset: 10-20 minutes
• Best for: Larger volume injections
• Sites: Deltoid, vastus lateralis, gluteus

Timing Strategies

Fasted State Administration

Many peptides work best on an empty stomach:

• Wait 2-3 hours after last meal
• Avoid eating for 30-60 minutes post-injection
• Particularly important for GH-releasing peptides

Circadian Optimization

Align peptide use with natural rhythms:

• Morning: MOTS-c, cognitive enhancers
• Pre-workout: BPC-157, TB-500
• Evening: GH secretagogues, sleep peptides
• Before bed: Epithalon, recovery peptides

Enhancing Absorption

Reconstitution Best Practices

• Use bacteriostatic water for multi-dose vials
• Add water slowly down the vial side
• Gently swirl, never shake
• Store properly: 2-8°C for most peptides

Complementary Supplements

Support peptide function with:

• Zinc & Magnesium: Enhance GH release
• Vitamin B Complex: Support methylation
• Omega-3s: Reduce inflammation
• Glycine: Improve sleep quality with GH peptides

Common Mistakes to Avoid

• Injecting too quickly (causes discomfort)
• Using expired or improperly stored peptides
• Taking peptides with food when fasted state is optimal
• Not rotating injection sites
• Mixing incompatible peptides in same syringe