KPV (Lys-Pro-Val) is a C-terminal tripeptide fragment of alpha-melanocyte-stimulating hormone (a-MSH). Despite consisting of only three amino acids, KPV has been shown in published research to enter cells and directly interact with inflammatory signaling cascades, including NF-kB nuclear translocation. It represents one of the smallest bioactive peptide sequences identified in endocrinology, demonstrating that biological potency is not proportional to molecular size.

Three amino acids. That is all it takes for this peptide to modulate one of the most powerful signaling pathways in cell biology. The molecular language of biology is not verbose — it is precise. KPV demonstrates that extraordinary functional complexity can be encoded into the simplest possible molecular structures. The elegance of this architecture — maximum biological information in minimum molecular space — reflects a remarkable economy of means.

At 99%+ purity (HPLC verified), our KPV supports research into MSH-derived peptide signaling, NF-kB pathway modulation, and minimal bioactive peptide sequences.